The Capsular Polysaccharide Vi fromSalmonellaTyphi Is a B1b Antigen
نویسندگان
چکیده
منابع مشابه
The capsular polysaccharide Vi from Salmonella typhi is a B1b antigen.
Vaccination with purified capsular polysaccharide Vi Ag from Salmonella typhi can protect against typhoid fever, although the mechanism for its efficacy is not clearly established. In this study, we have characterized the B cell response to this vaccine in wild-type and T cell-deficient mice. We show that immunization with typhoid Vi polysaccharide vaccine rapidly induces proliferation in B1b p...
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Characterization of Salmonella enterica Serovar Typhi isolates for their Vi capsular polysaccharide antigen-related genetic sequences is desirable to define the role of isolates lacking such sequences in differential replication at unusual sites, including those coinfected with human immunodeficiency virus (HIV). Infection with Vi-negative strains might produce typhoid fever among those immuniz...
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The role of Vi-capsular polysaccharide (Vi-CPS) in human immunity against infection caused by Salmonella typhi is well known. The downstream process of purification generally causes depolymerization of Vi-CPS to a nonimmunogenic low molecular weight form. In the present study, a standard strain of Sal. typhi Ty6s was grown under submerge cultural conditions in a pilot-plant scale of 90 Liter fe...
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In their paper entitled "Comparison of the PREMIER Cryptococcal Antigen Enzyme Immunoassay and the Latex Agglutination Assay for Detection of Cryptococcal Antigens" (1), Gade et al. compare a new enzyme immunoassay (EIA) for the detection and quantification of circulating capsular polysaccharide antigen from Cryptococcus neoformans with the latex agglutination (LA) test performed with a commerc...
متن کاملEffectiveness of Vi capsular polysaccharide typhoid vaccine among children: a cluster randomized trial in Karachi, Pakistan.
BACKGROUND Typhoid fever is endemic in Karachi, with an incidence among children ranging from 170 to 450 per 100,000 child-years. Vaccination strategies are important for prevention, and the Vi capsular polysaccharide (ViCPS) vaccine has been shown to be effective in reducing the burden of typhoid fever. METHODS A cluster randomized trial was conducted in three low socioeconomic urban squatte...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2012
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1103166